In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys()

We have developed a selective indole antagonist (230) targeting the OXE receptor for the potent eosinophil chemoattractant 5-oxo-ETE (5-oxo-6,8,11,14-eicosatetraenoic acid), that may be useful for the treatment of eosinophilic diseases such as asthma. In previous studies we identified ω2-oxidation o...

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Detalhes bibliográficos
Publicado no:Biochem Pharmacol
Main Authors: Chourey, Shishir, Ye, Qiuji, Reddy, Chintam Nagendra, Cossette, Chantal, Gravel, Sylvie, Zeller, Matthias, Slobodchikova, Irina, Vuckovic, Dajana, Rokach, Joshua, Powell, William S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710753/
https://ncbi.nlm.nih.gov/pubmed/28476332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.04.031
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