Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys

BACKGROUND AND PURPOSE: The 5‐lipoxygenase product 5‐oxo‐6E,8Z,11Z,14Z‐eicosatetraenoic acid (5‐oxo‐ETE), acting through the OXE receptor, is a potent eosinophil chemoattractant that may be an important proinflammatory mediator in eosinophilic diseases such as asthma. We previously identified a seri...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Ye, Qiuji, Chourey, Shishir, Reddy, Chintam Nagendra, Wang, Rui, Cossette, Chantal, Gravel, Sylvie, Slobodchikova, Irina, Vuckovic, Dajana, Rokach, Joshua, Powell, William S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989946/
https://ncbi.nlm.nih.gov/pubmed/31655025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14874
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