Inhibition of 5-oxo-6,8,11,14-eicosatetraenoic acid-induced Activation of Neutrophils and Eosinophils by Novel Indole OXE Receptor Antagonists

5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is a 5-lipoxygenase product that is a potent granulocyte chemoattractant, which induces the infiltration of eosinophils into human skin when injected intradermally. It could therefore be an important proinflammatory mediator in eosinophilic diseases...

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Udgivet i:J Med Chem
Main Authors: Gore, Vivek, Gravel, Sylvie, Cossette, Chantal, Patel, Pranav, Chourey, Shishir, Ye, Qiuji, Rokach, Joshua, Powell, William S.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138454/
https://ncbi.nlm.nih.gov/pubmed/24351031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401292m
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