Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine–Induced Hand-Foot Syndrome: A Randomized Clinical Trial

IMPORTANCE: Hand-foot syndrome (HFS) is a common adverse effect of capecitabine treatment. OBJECTIVE: To compare the incidence and time to onset of grade 2 or greater HFS in patients receiving pyridoxine vs placebo and to identify biomarkers predictive of HFS. DESIGN, SETTING, AND PARTICIPANTS: This...

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Detalles Bibliográficos
Publicado en:JAMA Oncol
Main Authors: Yap, Yoon-Sim, Kwok, Li-Lian, Syn, Nicholas, Chay, Wen Yee, Chia, John Whay Kuang, Tham, Chee Kian, Wong, Nan Soon, Lo, Soo Kien, Dent, Rebecca Alexandra, Tan, Sili, Mok, Zuan Yu, Koh, King Xin, Toh, Han Chong, Koo, Wen Hsin, Loh, Marie, Ng, Raymond Chee Hui, Choo, Su Pin, Soong, Richie Chuan Teck
Formato: Artigo
Idioma:Inglês
Publicado: American Medical Association 2017
Assuntos:
Original Investigation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710192/
https://ncbi.nlm.nih.gov/pubmed/28715540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2017.1269
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