Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine–Induced Hand-Foot Syndrome: A Randomized Clinical Trial

IMPORTANCE: Hand-foot syndrome (HFS) is a common adverse effect of capecitabine treatment. OBJECTIVE: To compare the incidence and time to onset of grade 2 or greater HFS in patients receiving pyridoxine vs placebo and to identify biomarkers predictive of HFS. DESIGN, SETTING, AND PARTICIPANTS: This...

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Udgivet i:JAMA Oncol
Main Authors: Yap, Yoon-Sim, Kwok, Li-Lian, Syn, Nicholas, Chay, Wen Yee, Chia, John Whay Kuang, Tham, Chee Kian, Wong, Nan Soon, Lo, Soo Kien, Dent, Rebecca Alexandra, Tan, Sili, Mok, Zuan Yu, Koh, King Xin, Toh, Han Chong, Koo, Wen Hsin, Loh, Marie, Ng, Raymond Chee Hui, Choo, Su Pin, Soong, Richie Chuan Teck
Format: Artigo
Sprog:Inglês
Udgivet: American Medical Association 2017
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Original Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710192/
https://ncbi.nlm.nih.gov/pubmed/28715540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2017.1269
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