Candidate mechanisms for capecitabine-related hand–foot syndrome

AIMS: The oral fluoropyrimidine prodrug capecitabine is widely used in oncology. Capecitabine was designed to generate 5FU via the thymidine phosphorylase (TP) enzyme, preferentially expressed in tumoral tissues. Hand–foot syndrome (HFS) is a limiting toxicity of capecitabine. A pilot study on healt...

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Detalhes bibliográficos
Main Authors: Milano, Gérard, Etienne-Grimaldi, Marie-Christine, Mari, Mireille, Lassalle, Sandra, Formento, Jean-Louis, Francoual, Mireille, Lacour, Jean-Philippe, Hofman, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Drug Safety
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2485249/
https://ncbi.nlm.nih.gov/pubmed/18341672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03159.x
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