Candidate mechanisms for capecitabine-related hand–foot syndrome

AIMS: The oral fluoropyrimidine prodrug capecitabine is widely used in oncology. Capecitabine was designed to generate 5FU via the thymidine phosphorylase (TP) enzyme, preferentially expressed in tumoral tissues. Hand–foot syndrome (HFS) is a limiting toxicity of capecitabine. A pilot study on healt...

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Библиографические подробности
Главные авторы: Milano, Gérard, Etienne-Grimaldi, Marie-Christine, Mari, Mireille, Lassalle, Sandra, Formento, Jean-Louis, Francoual, Mireille, Lacour, Jean-Philippe, Hofman, Paul
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Science Inc 2008
Предметы:
Drug Safety
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2485249/
https://ncbi.nlm.nih.gov/pubmed/18341672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03159.x
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