Dihydropyrimidine dehydrogenase activity and the IVS14+1G>A mutation in patients developing 5FU-related toxicity

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Dihydropyrimidine dehydrogenase (DPD) deficiency is known to be a major cause of severe 5FU-related toxicity. A link has been previously shown between 5FU toxicity and either low enzyme activity measured in peripheral blood mononuclear cells (PMNC) or germin...

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Main Authors: Magné, Nicolas, Etienne-Grimaldi, Marie-Christine, Cals, Laurent, Renée, Nicole, Formento, Jean-Louis, Francoual, Mireille, Milano, Gérard
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2007
Assuntos:
Short Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000632/
https://ncbi.nlm.nih.gov/pubmed/17335544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02869.x
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