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Dihydropyrimidine dehydrogenase activity and the IVS14+1G>A mutation in patients developing 5FU-related toxicity
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Dihydropyrimidine dehydrogenase (DPD) deficiency is known to be a major cause of severe 5FU-related toxicity. A link has been previously shown between 5FU toxicity and either low enzyme activity measured in peripheral blood mononuclear cells (PMNC) or germin...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Blackwell Science Inc
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2000632/ https://ncbi.nlm.nih.gov/pubmed/17335544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02869.x |
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