Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways

Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by these mutations, whether dependent or not on the oncometabolite D‐2‐hydroxyglut...

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Detaylı Bibliyografya
Yayımlandı:EMBO Mol Med
Asıl Yazarlar: Fack, Fred, Tardito, Saverio, Hochart, Guillaume, Oudin, Anais, Zheng, Liang, Fritah, Sabrina, Golebiewska, Anna, Nazarov, Petr V, Bernard, Amandine, Hau, Ann‐Christin, Keunen, Olivier, Leenders, William, Lund‐Johansen, Morten, Stauber, Jonathan, Gottlieb, Eyal, Bjerkvig, Rolf, Niclou, Simone P
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2017
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709746/
https://ncbi.nlm.nih.gov/pubmed/29054837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707729
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