Cystathionine-γ-lyase drives antioxidant defense in cysteine-restricted IDH1-mutant astrocytomas

BACKGROUND: Mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) define glioma subtypes and are considered primary events in gliomagenesis, impacting tumor epigenetics and metabolism. IDH enzyme activity is crucial for the generation of reducing potential in normal cells, yet the impact of the muta...

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Detalles Bibliográficos
Publicado en:Neurooncol Adv
Autores principales: Cano-Galiano, Andrés, Oudin, Anais, Fack, Fred, Allega, Maria-Francesca, Sumpton, David, Martinez-Garcia, Elena, Dittmar, Gunnar, Hau, Ann-Christin, De Falco, Alfonso, Herold-Mende, Christel, Bjerkvig, Rolf, Meiser, Johannes, Tardito, Saverio, Niclou, Simone P
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2021
Materias:
Basic and Translational Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262642/
https://ncbi.nlm.nih.gov/pubmed/34250481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab057
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