Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways

Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by these mutations, whether dependent or not on the oncometabolite D‐2‐hydroxyglut...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Fack, Fred, Tardito, Saverio, Hochart, Guillaume, Oudin, Anais, Zheng, Liang, Fritah, Sabrina, Golebiewska, Anna, Nazarov, Petr V, Bernard, Amandine, Hau, Ann‐Christin, Keunen, Olivier, Leenders, William, Lund‐Johansen, Morten, Stauber, Jonathan, Gottlieb, Eyal, Bjerkvig, Rolf, Niclou, Simone P
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709746/
https://ncbi.nlm.nih.gov/pubmed/29054837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707729
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