IN SITU METABOLIC PROFILING SHEDS LIGHT ON OXIDATIVE STRESS PATHWAYS IN IDH1 MUTANT OLIGODENDROGLIOMA

BACKGROUND: The oncometabolite D-2-hydroxyglutarate (2-HG) is strongly increased in glial tumors presenting a heterozygous point mutation in isocitrate dehydrogenase (IDH) and is a key indicator of aberrant metabolic circuitries in these tumors. IDH1 is a dimeric enzyme converting isocitrate to α-ke...

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Main Authors: Niclou, Simone P., Fack, Fred, Hochart, Guillaume, Oudin, Anais, Leenders, William, Gottlieb, Eyal, Bjerkvig, Rolf, Stauber, Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144505/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou206.39
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