Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG

BACKGROUND: Point mutations in genes encoding NADP(+)-dependent isocitrate dehydrogenases (especially IDH1) are common in lower grade diffuse gliomas and secondary glioblastomas and occur early during tumor development. The contribution of these mutations to gliomagenesis is not completely understoo...

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Detalhes bibliográficos
Main Authors: Navis, Anna C, Niclou, Simone P, Fack, Fred, Stieber, Daniel, van Lith, Sanne, Verrijp, Kiek, Wright, Alan, Stauber, Jonathan, Tops, Bastiaan, Otte-Holler, Irene, Wevers, Ron A, van Rooij, Arno, Pusch, Stefan, von Deimling, Andreas, Tigchelaar, Wikky, van Noorden, Cornelis JF, Wesseling, Pieter, Leenders, William PJ
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893588/
https://ncbi.nlm.nih.gov/pubmed/24252742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-18
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