CRISPR/Cas9-based safe-harbor gene editing in rhesus iPSCs

NHP iPSCs provide a unique opportunity to test safety and efficacy of iPSC-derived therapies in clinically relevant NHP models. To monitor these cells in vivo, there is a need for safe and efficient labeling methods. Gene insertion into genomic safe harbors (GSHs) supports reliable transgene express...

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Udgivet i:Curr Protoc Stem Cell Biol
Main Authors: Yada, Ravi Chandra, Ostrominski, John W., Tunc, Ilker, Hong, So Gun, Zou, Jizhong, Dunbar, Cynthia E.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709051/
https://ncbi.nlm.nih.gov/pubmed/29140568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpsc.37
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