Rhesus iPSC Safe Harbor Gene-Editing Platform for Stable Expression of Transgenes in Differentiated Cells of All Germ Layers

Nonhuman primate (NHP) induced pluripotent stem cells (iPSCs) offer the opportunity to investigate the safety, feasibility, and efficacy of proposed iPSC-derived cellular delivery in clinically relevant in vivo models. However, there is need for stable, robust, and safe labeling methods for NHP iPSC...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Hong, So Gun, Yada, Ravi Chandra, Choi, Kyujoo, Carpentier, Arnaud, Liang, T. Jake, Merling, Randall K., Sweeney, Colin L., Malech, Harry L., Jung, Moonjung, Corat, Marcus A.F., AlJanahi, Aisha A., Lin, Yongshun, Liu, Huimin, Tunc, Ilker, Wang, Xujing, Palisoc, Maryknoll, Pittaluga, Stefania, Boehm, Manfred, Winkler, Thomas, Zou, Jizhong, Dunbar, Cynthia E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363312/
https://ncbi.nlm.nih.gov/pubmed/28129126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.10.007
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