Rhesus iPSC Safe Harbor Gene-Editing Platform for Stable Expression of Transgenes in Differentiated Cells of All Germ Layers

Nonhuman primate (NHP) induced pluripotent stem cells (iPSCs) offer the opportunity to investigate the safety, feasibility, and efficacy of proposed iPSC-derived cellular delivery in clinically relevant in vivo models. However, there is need for stable, robust, and safe labeling methods for NHP iPSC...

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Pubblicato in:Mol Ther
Autori principali: Hong, So Gun, Yada, Ravi Chandra, Choi, Kyujoo, Carpentier, Arnaud, Liang, T. Jake, Merling, Randall K., Sweeney, Colin L., Malech, Harry L., Jung, Moonjung, Corat, Marcus A.F., AlJanahi, Aisha A., Lin, Yongshun, Liu, Huimin, Tunc, Ilker, Wang, Xujing, Palisoc, Maryknoll, Pittaluga, Stefania, Boehm, Manfred, Winkler, Thomas, Zou, Jizhong, Dunbar, Cynthia E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363312/
https://ncbi.nlm.nih.gov/pubmed/28129126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.10.007
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