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CRISPR/Cas-edited iPSCs and mesenchymal stem cells: a concise review of their potential in thalassemia therapy

Thalassemia, a prevalent single-gene inherited disorder, relies on hematopoietic stem cell or bone marrow transplantation as its definitive treatment. However, the scarcity of suitable donors and the severe complications from anemia and iron overload pose significant challenges. An immediate need ex...

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Autors principals: Jiaojiao Shu, Xin Xie, Sixi Wang, Zuochen Du, Pei Huang, Yan Chen, Zhixu He
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2025-09-01
Col·lecció:Frontiers in Cell and Developmental Biology
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fcell.2025.1595897/full
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