A non-threshold region-specific method for detecting rare variants in complex diseases

A region-specific method, NTR (non-threshold rare) variant detection method, was developed—it does not use the threshold for defining rare variants and accounts for directions of effects. NTR also considers linkage disequilibrium within the region and accommodates common and rare variants simultaneo...

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Vydáno v:PLoS One
Hlavní autoři: Hsieh, Ai-Ru, Chen, Dao-Peng, Chattopadhyay, Amrita Sengupta, Li, Ying-Ju, Chang, Chien-Ching, Fann, Cathy S. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708778/
https://ncbi.nlm.nih.gov/pubmed/29190701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188566
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