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Determining population stratification and subgroup effects in association studies of rare genetic variants for nicotine dependence

BACKGROUND: Rare variants (minor allele frequency < 1% or 5 %) can help researchers to deal with the confounding issue of ‘missing heritability’ and have a proven role in dissecting the etiology for human diseases and complex traits. METHODS: We extended the combined multivariate and collapsing (...

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Detalhes bibliográficos
Publicado no:Psychiatr Genet
Main Authors: Hsieh, Ai-Ru, Chen, Li-Shiun, Li, Ying-Ju, Fann, Cathy S.J.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6636808/
https://ncbi.nlm.nih.gov/pubmed/31033776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/YPG.0000000000000227
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