Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity

Plasmodium falciparum HKMTs (PfHKMTs) play a key role in controlling Plasmodium gene expression and represent exciting new anti-malarial epigenetic targets. Using an inhibitor series derived from the diaminoquinazoline HKMT inhibitory chemotype, we have previously identified compounds with highly pr...

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Publicat a:Medchemcomm
Autors principals: Sundriyal, Sandeep, Chen, Patty B., Lubin, Alexandra S., Lueg, Gregor A., Li, Fengling, White, Andrew J. P., Malmquist, Nicholas A., Vedadi, Masoud, Scherf, Artur, Fuchter, Matthew J.
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2017
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708365/
https://ncbi.nlm.nih.gov/pubmed/29308121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00052a
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