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Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF(5)-substituted oxindoles with a range of aldehydes. The resulting products were characterized by X-ray crystallography studies and were...

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Publicat a:Org Biomol Chem
Autors principals: Sansook, Supojjanee, Ocasio, Cory A., Day, Iain J., Tizzard, Graham J., Coles, Simon J., Fedorov, Oleg, Bennett, James M., Elkins, Jonathan M., Spencer, John
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708334/
https://ncbi.nlm.nih.gov/pubmed/28984325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob02289a
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