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Probing the Anticancer Action of Novel Ferrocene Analogues of MNK Inhibitors
Two novel ferrocene-containing compounds based upon a known MNK1/2 kinase (MAPK-interacting kinase) inhibitor have been synthesized. The compounds were designed to use the unique shape of ferrocene to exploit a large hydrophobic pocket in MNK1/2 that is only partially occupied by the original compou...
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| Publicado no: | Molecules |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6225114/ https://ncbi.nlm.nih.gov/pubmed/30142961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23092126 |
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