A chimeric haemagglutinin-based influenza split virion vaccine adjuvanted with AS03 induces protective stalk-reactive antibodies in mice

Seasonal influenza virus vaccines are generally effective at preventing disease, but need to be well matched to circulating virus strains for maximum benefit. Influenza viruses constantly undergo antigenic changes because of their high mutation rate in the immunodominant haemagglutinin (HA) head dom...

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Detalhes bibliográficos
Publicado no:NPJ Vaccines
Main Authors: Nachbagauer, Raffael, Kinzler, David, Choi, Angela, Hirsh, Ariana, Beaulieu, Edith, Lecrenier, Nicolas, Innis, Bruce L, Palese, Peter, Mallett, Corey P, Krammer, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707880/
https://ncbi.nlm.nih.gov/pubmed/29250436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npjvaccines.2016.15
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