H3 Stalk-Based Chimeric Hemagglutinin Influenza Virus Constructs Protect Mice from H7N9 Challenge

The recent outbreak of H7N9 influenza virus infections in humans in China has raised concerns about the pandemic potential of this strain. Here, we test the efficacy of H3 stalk-based chimeric hemagglutinin universal influenza virus vaccine constructs to protect against H7N9 challenge in mice. Chime...

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Bibliographic Details
Main Authors: Krammer, Florian, Margine, Irina, Hai, Rong, Flood, Alexander, Hirsh, Ariana, Tsvetnitsky, Vadim, Chen, Dexiang, Palese, Peter
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911549/
https://ncbi.nlm.nih.gov/pubmed/24307585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03183-13
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