Epigenetic silencing of miR-296 and miR-512 ensures hTERT dependent apoptosis protection and telomere maintenance in basal-type breast cancer cells

The catalytic subunit of the telomerase complex, hTERT, ensures unlimited proliferative potential of cancer cells by maintaining telomere function and protecting from apoptosis. Using a miRNA screening approach we identified miR-296-5p and miR-512-5p as miRNAs that target hTERT in breast cancer cell...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Dinami, Roberto, Buemi, Valentina, Sestito, Rosanna, Zappone, Antonina, Ciani, Yari, Mano, Miguel, Petti, Eleonora, Sacconi, Andrea, Blandino, Giovanni, Giacca, Mauro, Piazza, Silvano, Benetti, Roberta, Schoeftner, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707052/
https://ncbi.nlm.nih.gov/pubmed/29221158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21180
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