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Targeting endothelin 1 receptor-miR-200b/c-ZEB1 circuitry blunts metastatic progression in ovarian cancer

Identification of regulatory mechanisms underlying the poor prognosis of ovarian cancer is necessary for diagnostic and therapeutic implications. Here we show that endothelin A receptor (ET(A)R) and ZEB1 expression is upregulated in mesenchymal ovarian cancer and correlates with poor prognosis. Nota...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Sestito, Rosanna, Cianfrocca, Roberta, Tocci, Piera, Rosanò, Laura, Sacconi, Andrea, Blandino, Giovanni, Bagnato, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666224/
https://ncbi.nlm.nih.gov/pubmed/33188287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01404-3
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