SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

In vertebrates, the telomere repeat containing long, non-coding RNA TERRA is prone to form RNA:DNA hybrids at telomeres. This results in the formation of R-loop structures, replication stress and telomere instability, but also contributes to alternative lengthening of telomeres (ALT). Here, we ident...

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Publicado en:Nat Commun
Main Authors: Petti, Eleonora, Buemi, Valentina, Zappone, Antonina, Schillaci, Odessa, Broccia, Pamela Veneziano, Dinami, Roberto, Matteoni, Silvia, Benetti, Roberta, Schoeftner, Stefan
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397292/
https://ncbi.nlm.nih.gov/pubmed/30824709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08863-1
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