Pharmacokinetic Properties of DNA Aptamers with Base Modifications

The addition of novel side chains at the 5-position of uracil is an effective means to increase chemical diversity of aptamers and hence the success rate for discovery of high-affinity ligands to protein targets. Such modifications also increase nuclease resistance, which is useful in a range of app...

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Vydáno v:Nucleic Acid Ther
Hlavní autoři: Gupta, Shashi, Drolet, Daniel W., Wolk, Steven K., Waugh, Sheela M., Rohloff, John C., Carter, Jeffery D., Mayfield, Wesley S., Otis, Matthew R., Fowler, Catherine R., Suzuki, Tomoki, Hirota, Masao, Ishikawa, Yuichi, Schneider, Daniel J., Janjic, Nebojsa
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2017
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706628/
https://ncbi.nlm.nih.gov/pubmed/28961063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2017.0683
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