Pharmacokinetic Properties of DNA Aptamers with Base Modifications

The addition of novel side chains at the 5-position of uracil is an effective means to increase chemical diversity of aptamers and hence the success rate for discovery of high-affinity ligands to protein targets. Such modifications also increase nuclease resistance, which is useful in a range of app...

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Detalhes bibliográficos
Publicado no:Nucleic Acid Ther
Main Authors: Gupta, Shashi, Drolet, Daniel W., Wolk, Steven K., Waugh, Sheela M., Rohloff, John C., Carter, Jeffery D., Mayfield, Wesley S., Otis, Matthew R., Fowler, Catherine R., Suzuki, Tomoki, Hirota, Masao, Ishikawa, Yuichi, Schneider, Daniel J., Janjic, Nebojsa
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706628/
https://ncbi.nlm.nih.gov/pubmed/28961063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2017.0683
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