Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting

Unbalanced brain serotonin (5-HT) levels have implications in various behavioral abnormalities and neuropsychiatric disorders. The biosynthesis of neuronal 5-HT is regulated by the rate-limiting enzyme, tryptophan hydroxylase-2 (TPH2). In the present study, the clustered regularly interspaced short...

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Veröffentlicht in:J Biomed Res
Hauptverfasser: Li, Ze, Yang, Hai-Yuan, Wang, Ying, Zhang, Man-Ling, Liu, Xiao-Rui, Xiong, Qiang, Zhang, Li-Ning, Jin, Yong, Mou, Li-Sha, Liu, Yan, Li, Rong-Feng, Rao, Yi, Dai, Yi-Fan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Editorial Department of Journal of Biomedical Research 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706437/
https://ncbi.nlm.nih.gov/pubmed/28866660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7555/JBR.31.20170026
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