Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting

Complement protein C3 is the pivotal component of the complement system. Previous studies have demonstrated that C3 has implications in various human diseases and exerts profound functions under certain conditions. However, the delineation of pathological and physiological roles of C3 has been hampe...

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Pubblicato in:Sci Rep
Autori principali: Zhang, Wei, Wang, Guan, Wang, Ying, Jin, Yong, Zhao, Lihua, Xiong, Qiang, Zhang, Lining, Mou, Lisha, Li, Rongfeng, Yang, Haiyuan, Dai, Yifan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503937/
https://ncbi.nlm.nih.gov/pubmed/28694465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05400-2
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