Production of α1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning

Gene-knockout pigs hold great promise as a solution to the shortage of organs from donor animals for xenotransplantation. Several groups have generated gene-knockout pigs via clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) and somatic cell nuclear transf...

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Detalhes bibliográficos
Publicado no:J Reprod Dev
Main Authors: GAO, Hanchao, ZHAO, Chengjiang, XIANG, Xi, LI, Yong, ZHAO, Yanli, LI, Zesong, PAN, Dengke, DAI, Yifan, HARA, Hidetaka, COOPER, David K.C., CAI, Zhiming, MOU, Lisha
Formato: Artigo
Idioma:Inglês
Publicado em: The Society for Reproduction and Development 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320426/
https://ncbi.nlm.nih.gov/pubmed/27725344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1262/jrd.2016-079
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