Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs

Miniature pigs have advantages over rodents in modeling atherosclerosis because their cardiovascular system and physiology are similar to that of humans. Apolipoprotein E (ApoE) deficiency has long been implicated in cardiovascular disease in humans. To establish an improved large animal model of fa...

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Detalhes bibliográficos
Main Authors: Bin Fang, Xueyang Ren, Ying Wang, Ze Li, Lihua Zhao, Manling Zhang, Chu Li, Zhengwei Zhang, Lei Chen, Xiaoxue Li, Jiying Liu, Qiang Xiong, Lining Zhang, Yong Jin, Xiaorui Liu, Lin Li, Hong Wei, Haiyuan Yang, Rongfeng Li, Yifan Dai
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2018-10-01
Colecção:Disease Models & Mechanisms
Assuntos:
Atherosclerosis
ApoE
Bama miniature pigs
CRISPR/Cas9
Acesso em linha:http://dmm.biologists.org/content/11/10/dmm036632
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