CRISPR/Cas9-mediated ApoE(-/-) and LDLR(-/-) double gene knockout in pigs elevates serum LDL-C and TC levels

The traditional method to establish a cardiovascular disease model induced by high fat and high cholesterol diets is time consuming and laborious and may not be appropriate in all circumstances. A suitable pig model to study metabolic disorders and subsequent atherosclerosis is not currently availab...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Huang, Lei, Hua, Zaidong, Xiao, Hongwei, Cheng, Ying, Xu, Kui, Gao, Qian, Xia, Ying, Liu, Yang, Zhang, Xue, Zheng, Xinming, Mu, Yulian, Li, Kui
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514946/
https://ncbi.nlm.nih.gov/pubmed/28465483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17154
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