Blockade of deubiquitylating enzyme Rpn11 triggers apoptosis in multiple myeloma cells and overcomes bortezomib resistance

Proteasome inhibition is an effective therapy for multiple myeloma (MM) patients; however, the emergence of drug resistance is common. Novel therapeutic strategies to overcome proteasome inhibitor resistance are needed. In this study, we examined whether targeting deubiquitylating (DUB) enzymes upst...

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Bibliographic Details
Published in:	Oncogene
Main Authors:	Song, Y, Li, S, Ray, A, Das, DS, Qi, J, Samur, MK, Tai, Y-T, Munshi, N, Carrasco, RD, Chauhan, D, Anderson, KC
Format:	Artigo
Language:	Inglês
Published:	2017
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5705032/ https://ncbi.nlm.nih.gov/pubmed/28581522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.172
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Blockade of deubiquitylating enzyme Rpn11 triggers apoptosis in multiple myeloma cells and overcomes bortezomib resistance

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