Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations

BACKGROUND: Previous studies have indicated that tumor mitochondrial DNA (mtDNA) mutations are primarily shaped by relaxed negative selection, which is contradictory to the critical roles of mtDNA mutations in tumorigenesis. Therefore, we hypothesized that site-specific selection may influence tumor...

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Detaylı Bibliyografya
Yayımlandı:J Exp Clin Cancer Res
Asıl Yazarlar: Li, Deyang, Du, Xiaohong, Guo, Xu, Zhan, Lei, Li, Xin, Yin, Chun, Chen, Cheng, Li, Mingkun, Li, Bingshan, Yang, Hushan, Xing, Jinliang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2017
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704541/
https://ncbi.nlm.nih.gov/pubmed/29179728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0638-6
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