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Extensive tissue-related and allele-related mtDNA heteroplasmy suggests positive selection for somatic mutations
Heteroplasmy in human mtDNA may play a role in cancer, other diseases, and aging, but patterns of heteroplasmy variation across different tissues have not been thoroughly investigated. Here, we analyzed complete mtDNA genome sequences at ∼3,500× average coverage from each of 12 tissues obtained at a...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4345623/ https://ncbi.nlm.nih.gov/pubmed/25675502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419651112 |
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