Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations

BACKGROUND: Previous studies have indicated that tumor mitochondrial DNA (mtDNA) mutations are primarily shaped by relaxed negative selection, which is contradictory to the critical roles of mtDNA mutations in tumorigenesis. Therefore, we hypothesized that site-specific selection may influence tumor...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Li, Deyang, Du, Xiaohong, Guo, Xu, Zhan, Lei, Li, Xin, Yin, Chun, Chen, Cheng, Li, Mingkun, Li, Bingshan, Yang, Hushan, Xing, Jinliang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704541/
https://ncbi.nlm.nih.gov/pubmed/29179728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0638-6
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