Soluble F proteins exacerbate pulmonary histopathology after vaccination upon respiratory syncytial virus challenge but not when presented on virus-like particles

Respiratory syncytial virus (RSV) fusion (F) protein is suggested to be a protective vaccine target although its efficacy and safety concerns remain not well understood. We investigated immunogenicity, efficacy, and safety of F proteins in a soluble form or on virus-like particle (F-VLP). F VLP pref...

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Bibliographische Detailangaben
Veröffentlicht in:Hum Vaccin Immunother
Hauptverfasser: Lee, Youri, Lee, Young-Tae, Ko, Eun-Ju, Kim, Ki-Hye, Hwang, Hye Suk, Park, Soojin, Kwon, Young-Man, Kang, Sang Moo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703400/
https://ncbi.nlm.nih.gov/pubmed/28854003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2017.1362514
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