Soluble F proteins exacerbate pulmonary histopathology after vaccination upon respiratory syncytial virus challenge but not when presented on virus-like particles

Respiratory syncytial virus (RSV) fusion (F) protein is suggested to be a protective vaccine target although its efficacy and safety concerns remain not well understood. We investigated immunogenicity, efficacy, and safety of F proteins in a soluble form or on virus-like particle (F-VLP). F VLP pref...

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Detalhes bibliográficos
Publicado no:Hum Vaccin Immunother
Main Authors: Lee, Youri, Lee, Young-Tae, Ko, Eun-Ju, Kim, Ki-Hye, Hwang, Hye Suk, Park, Soojin, Kwon, Young-Man, Kang, Sang Moo
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703400/
https://ncbi.nlm.nih.gov/pubmed/28854003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2017.1362514
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