A unique combination adjuvant modulates immune responses preventing vaccine-enhanced pulmonary histopathology after a single dose vaccination with fusion protein and challenge with respiratory syncytial virus

Alum adjuvanted formalin-inactivated respiratory syncytial virus (RSV) vaccination resulted in enhanced respiratory disease in young children upon natural infection. Here, we investigated the adjuvant effects of monophosphoryl lipid A (MPL) and oligodeoxynucleotide CpG (CpG) on vaccine-enhanced resp...

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Gepubliceerd in:Virology
Hoofdauteurs: Lee, Youri, Ko, Eun-Ju, Kim, Ki-Hye, Lee, Young-Tae, Hwang, Hye Suk, Kwon, Young-Man, Graham, Barney S., Kang, Sang Moo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642440/
https://ncbi.nlm.nih.gov/pubmed/31163351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2019.05.010
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