The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain

Facioscapulohumeral muscular dystrophy (FSHD) is caused by inappropriate expression of the double homeodomain protein DUX4. DUX4 has bimodal effects, inhibiting myogenic differentiation and blocking MyoD at low levels of expression, and killing myoblasts at high levels. Pax3 and Pax7, which contain...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Bosnakovski, Darko, Toso, Erik A., Hartweck, Lynn M., Magli, Alessandro, Lee, Heather A., Thompson, Eliza R., Dandapat, Abhijit, Perlingeiro, Rita C. R., Kyba, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702055/
https://ncbi.nlm.nih.gov/pubmed/28935672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.205427
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