The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain

Facioscapulohumeral muscular dystrophy (FSHD) is caused by inappropriate expression of the double homeodomain protein DUX4. DUX4 has bimodal effects, inhibiting myogenic differentiation and blocking MyoD at low levels of expression, and killing myoblasts at high levels. Pax3 and Pax7, which contain...

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Dettagli Bibliografici
Pubblicato in:J Cell Sci
Autori principali: Bosnakovski, Darko, Toso, Erik A., Hartweck, Lynn M., Magli, Alessandro, Lee, Heather A., Thompson, Eliza R., Dandapat, Abhijit, Perlingeiro, Rita C. R., Kyba, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702055/
https://ncbi.nlm.nih.gov/pubmed/28935672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.205427
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