Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene

Facioscapulohumeral muscular dystrophy (FSHD) is an enigmatic disease associated with epigenetic alterations in the subtelomeric heterochromatin of the D4Z4 macrosatellite repeat. Each repeat unit encodes DUX4, a gene that is normally silent in most tissues. Besides muscular loss, most patients suff...

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主要な著者: Dandapat, Abhijit, Bosnakovski, Darko, Hartweck, Lynn M., Arpke, Robert W., Baltgalvis, Kristen A., Vang, Derek, Baik, June, Darabi, Radbod, Perlingeiro, RitaC.R., Hamra, F. Kent, Gupta, Kalpna, Lowe, Dawn A., Kyba, Michael
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188423/
https://ncbi.nlm.nih.gov/pubmed/25176645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.056
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