The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor

Mature T cells bearing αβ T cell receptors react with foreign antigens bound to alleles of major histocompatibility complex proteins (MHC) that they were exposed to during their development in the thymus, a phenomenon known as positive selection. The structural basis for positive selection has long...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Marrack, Philippa, Krovi, Sai Harsha, Silberman, Daniel, White, Janice, Kushnir, Eleanor, Nakayama, Maki, Crooks, James, Danhorn, Thomas, Leach, Sonia, Anselment, Randy, Scott-Browne, James, Gapin, Laurent, Kappler, John
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701794/
https://ncbi.nlm.nih.gov/pubmed/29148973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30918
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