Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors

The interaction of αβ T-cell antigen receptors (TCRs) with peptides bound to MHC molecules lies at the center of adaptive immunity. Whether TCRs have evolved to react with MHC or, instead, processes in the thymus involving coreceptors and other molecules select MHC-specific TCRs de novo from a rando...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Silberman, Daniel, Krovi, Sai Harsha, Tuttle, Kathryn D., Crooks, James, Reisdorph, Richard, White, Janice, Gross, James, Matsuda, Jennifer L., Gapin, Laurent, Marrack, Philippa, Kappler, John W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035841/
https://ncbi.nlm.nih.gov/pubmed/27588903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609717113
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