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Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors
The interaction of αβ T-cell antigen receptors (TCRs) with peptides bound to MHC molecules lies at the center of adaptive immunity. Whether TCRs have evolved to react with MHC or, instead, processes in the thymus involving coreceptors and other molecules select MHC-specific TCRs de novo from a rando...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5035841/ https://ncbi.nlm.nih.gov/pubmed/27588903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609717113 |
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