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Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors

The interaction of αβ T-cell antigen receptors (TCRs) with peptides bound to MHC molecules lies at the center of adaptive immunity. Whether TCRs have evolved to react with MHC or, instead, processes in the thymus involving coreceptors and other molecules select MHC-specific TCRs de novo from a rando...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Silberman, Daniel, Krovi, Sai Harsha, Tuttle, Kathryn D., Crooks, James, Reisdorph, Richard, White, Janice, Gross, James, Matsuda, Jennifer L., Gapin, Laurent, Marrack, Philippa, Kappler, John W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035841/
https://ncbi.nlm.nih.gov/pubmed/27588903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609717113
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