Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors

The interaction of αβ T-cell antigen receptors (TCRs) with peptides bound to MHC molecules lies at the center of adaptive immunity. Whether TCRs have evolved to react with MHC or, instead, processes in the thymus involving coreceptors and other molecules select MHC-specific TCRs de novo from a rando...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Silberman, Daniel, Krovi, Sai Harsha, Tuttle, Kathryn D., Crooks, James, Reisdorph, Richard, White, Janice, Gross, James, Matsuda, Jennifer L., Gapin, Laurent, Marrack, Philippa, Kappler, John W.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035841/
https://ncbi.nlm.nih.gov/pubmed/27588903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609717113
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