Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness

OBJECTIVE—: Mitochondrial DNA (mtDNA) damage is present in murine and human atherosclerotic plaques. However, whether endogenous levels of mtDNA damage are sufficient to cause mitochondrial dysfunction and whether decreasing mtDNA damage and improving mitochondrial respiration affects plaque burden...

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Foilsithe in:Arterioscler Thromb Vasc Biol
Main Authors: Yu, Emma P.K., Reinhold, Johannes, Yu, Haixiang, Starks, Lakshi, Uryga, Anna K., Foote, Kirsty, Finigan, Alison, Figg, Nichola, Pung, Yuh-Fen, Logan, Angela, Murphy, Michael P., Bennett, Martin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Lippincott Williams & Wilkins 2017
Ábhair:
Translational Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701734/
https://ncbi.nlm.nih.gov/pubmed/28970293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.310042
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