SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis

Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis and features of plaque instability, in part, through lipid-mediated oxidative DNA damage and telomere dysfunction. SIRT6 (Sirtuin 6) is a nuclear deacetylase involved in DNA damage response signaling, inflammation, and metabolism...

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Bibliografske podrobnosti
izdano v:Circ Res
Main Authors: Grootaert, Mandy O.J., Finigan, Alison, Figg, Nichola L., Uryga, Anna K., Bennett, Martin R.
Format: Artigo
Jezik:Inglês
Izdano: Lippincott Williams & Wilkins 2020
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899748/
https://ncbi.nlm.nih.gov/pubmed/33353368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.120.318353
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