Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness

OBJECTIVE—: Mitochondrial DNA (mtDNA) damage is present in murine and human atherosclerotic plaques. However, whether endogenous levels of mtDNA damage are sufficient to cause mitochondrial dysfunction and whether decreasing mtDNA damage and improving mitochondrial respiration affects plaque burden...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Yu, Emma P.K., Reinhold, Johannes, Yu, Haixiang, Starks, Lakshi, Uryga, Anna K., Foote, Kirsty, Finigan, Alison, Figg, Nichola, Pung, Yuh-Fen, Logan, Angela, Murphy, Michael P., Bennett, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: Lippincott Williams & Wilkins 2017
Témata:
Translational Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701734/
https://ncbi.nlm.nih.gov/pubmed/28970293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.310042
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