Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness

OBJECTIVE—: Mitochondrial DNA (mtDNA) damage is present in murine and human atherosclerotic plaques. However, whether endogenous levels of mtDNA damage are sufficient to cause mitochondrial dysfunction and whether decreasing mtDNA damage and improving mitochondrial respiration affects plaque burden...

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Gepubliceerd in:Arterioscler Thromb Vasc Biol
Hoofdauteurs: Yu, Emma P.K., Reinhold, Johannes, Yu, Haixiang, Starks, Lakshi, Uryga, Anna K., Foote, Kirsty, Finigan, Alison, Figg, Nichola, Pung, Yuh-Fen, Logan, Angela, Murphy, Michael P., Bennett, Martin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Lippincott Williams & Wilkins 2017
Onderwerpen:
Translational Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701734/
https://ncbi.nlm.nih.gov/pubmed/28970293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.310042
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